Experimental model of intracranial aneurysms

Czech version

Authors: M. Hundža Stratilová ^1,2; K. Kárová ³; L. Machová Urdzíková ³; P. Jendelová ³; M. Koblížek ²; M. Sameš ¹; J. Zámečník ²; A. Hejčl ^1,3,4
Authors‘ workplace: Neurochirurgická klinika Fakulty zdravotnických studií univerzity J. E. Purkyně v Ústí nad Labem a Krajské zdravotní, a. s. – Masarykovy nemocnice v Ústí nad Labem, o. z. ¹; Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha ²; Ústav experimentální medicíny Akademie věd České republiky ³; Mezinárodní centrum klinického výzkumu, Fakultní nemocnice u sv. Anny v Brně ⁴
Published in: Cesk Slov Neurol N 2024; 87(2): 107-113
Category: Review Article
doi: https://doi.org/10.48095/cccsnn2024107

Overview

Rupture of an intracranial aneurysm represents a life-threatening condition with a still high mortality and morbidity. The pathogenesis of aneurysm development and eventual aneurysm rupture are still shrouded in mystery, representing a great field of research opportunities for scientists. Despite certain limitations, experimental models of intracranial aneurysms have their invaluable place. The review article summarizes the published results of current experimental rodent-focused models, their advantages, as well as limitations. At the same time, it introduces the reader to the results of our pilot study of an experimental laboratory mice model.

Keywords:

chronic inflammation – subarachnoid hemorrhage – intracranial aneurysm – experimental model – rodent model

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