Experimental model of intracranial aneurysms
Authors:
M. Hundža Stratilová 1,2; K. Kárová 3; L. Machová Urdzíková 3; P. Jendelová 3; M. Koblížek 2; M. Sameš 1; J. Zámečník 2; A. Hejčl 1,3,4
Authors‘ workplace:
Neurochirurgická klinika Fakulty zdravotnických studií univerzity J. E. Purkyně v Ústí nad Labem a Krajské zdravotní, a. s. – Masarykovy nemocnice v Ústí nad Labem, o. z.
1; Ústav patologie a molekulární medicíny 2. LF UK a FN Motol, Praha
2; Ústav experimentální medicíny Akademie věd České republiky
3; Mezinárodní centrum klinického výzkumu, Fakultní nemocnice u sv. Anny v Brně
4
Published in:
Cesk Slov Neurol N 2024; 87(2): 107-113
Category:
Review Article
doi:
https://doi.org/10.48095/cccsnn2024107
Overview
Rupture of an intracranial aneurysm represents a life-threatening condition with a still high mortality and morbidity. The pathogenesis of aneurysm development and eventual aneurysm rupture are still shrouded in mystery, representing a great field of research opportunities for scientists. Despite certain limitations, experimental models of intracranial aneurysms have their invaluable place. The review article summarizes the published results of current experimental rodent-focused models, their advantages, as well as limitations. At the same time, it introduces the reader to the results of our pilot study of an experimental laboratory mice model.
Keywords:
chronic inflammation – subarachnoid hemorrhage – intracranial aneurysm – experimental model – rodent model
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Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
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