Course of myelin oligodendrocyte glycoprotein-associated disease (MOGAD) – a cohort of patients

Czech version

Authors: P. Hanáková ^1,2; P. Danhofer ¹; M. Dufek ²; J. Šenkyřík ³; M. Komínek ⁴; P. Dominik ⁵; H. Ošlejšková ¹
Authors‘ workplace: Klinika dětské neurologie LF MU a FN Brno ¹; I. neurologická klinika LF MU a FN u sv. Anny, Brno ²; Klinika radiologie a nukleární medicíny LF MU a FN Brno ³; Dětská oční klinika LF MU a FN Brno ⁴; Klinika dětské anesteziologie a resuscitace LF MU a FN Brno ⁵
Published in: Cesk Slov Neurol N 2024; 87(2): 122-131
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn2024122

Overview

The aim of this paper is to provide a comprehensive overview of myelin-oligodendrocyte glycoprotein antibody-associated disease (MOGAD) and to provide our own practical experience with the diagnosis and treatment of this disease. We present a series of seven patients followed prospectively in our department from 1/2018 to 2/2023. Average age of children at the time of diagnosis was 11.4 ± 2.8 years. All patients fulfilled the MOGAD diagnostic criteria at the time. We present the individual cases and highlight the nature of the course of the disease and the pitfalls of treatment. We discuss acute and chronic therapy and point out the need for further prospective studies in children with MOGAD.

Keywords:

plasmapheresis – optic neuritis – myelitis – myelin-oligodendrocyte glycoprotein autoimmune demyelinating disorders – CNS

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