Proteomics of cerebrospinal fluid in pediatric oncology patients

Czech version

Authors: D. Zapletalová ^1*; P. Múdrý ^1*; P. Danhofer ²; M. E. Barrios-Llerena ³; H. Ošlejšková ²; J. Štěrba ¹
Authors‘ workplace: Klinika dětské onkologie, LF MU a FN Brno ¹; Centrum pro epilepsie, Klinika dětské, neurologie LF MU a FN Brno ²; Mezinárodní centrum klinického, výzkumu FNUsA Brno ³
Published in: Cesk Slov Neurol N 2021; 84/117(3): 245-249
Category: Review Article
doi: https://doi.org/10.48095/cccsnn2021245

Overview

Major technological advances in the last two decades have led to the rise of proteomic analyses in various fields of medicine. In oncology, cerebrospinal fluid proteomics focuses on the detection of biomarkers in primary CNS tumors and on the detection of CNS involvement secondarily or on the monitoring of neurological complications of treatment such as leukemias or lymphomas. Cytology may not be sensitive enough to detect such at-risk patients. In pediatric neuro-oncology, the diagnosis and subsequent treatment of CNS tumors is currently based almost exclusively on histological and molecular biological examination of tumor tissue. However, in a large number of patients, resection or mere biopsy of the tumor is not possible due to the proximity of vital centers. In these cases, a reliable bio marker could help, providing more detailed information on diagnosis, tumor classification, or risk assessment, or helping to identify potential treatment targets from better available bio logical material such as cerebrospinal fluid. CNS relapse occurs in 3–8% of children with acute lymphoblastic leukemia. In addition, patients with confirmed CNS leukemia tend to have a worse treatment outcome. During treatment, pediatric patients also face numerous complications, one of the most serious being those affecting the CNS. The authors present an overview of the results of current studies dealing with cerebrospinal fluid proteomics in pediatric oncological patients.

Keywords:

proteomics – biomarkers – child – CNS neoplasms – acute lymphoblastic leukemia

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