Protein S 100B a jeho prognostické možnosti u kraniocerebrálních traumat

Czech version

Authors: Š. Trnka; J. Jablonský; P. Stejskal; L. Hrabálek; M. Vaverka; D. Krahulík
Authors‘ workplace: Neurochirurgická klinika LF UP a FN Olomouc
Published in: Cesk Slov Neurol N 2021; 84(6): 562-566
Category: Short Communication
doi: https://doi.org/10.48095/cccsnn2021562

Overview

Aim: The aim of this study was to explore prognostic capabilities of protein S 100B as a possible biochemical marker in patients with traumatic brain injury. Materials and methods: In this pilot study, we enrolled 22 patients with a traumatic brain injury verified on CT. S 100B levels were measured within 3 h and later on after 8, 12, 24 and 72 h following the trauma. Results: Initial checks of levels within 3 h following the trauma proved to be at a peak median 0.624 (0.166; 1.250) μg/L, and in the following hours the values declined with statistical significance. We proved a significant moderate negative correlation between the values of protein S 100B measured at all time checkpoints with initial Glasgow Coma Scale (GCS) values, with the highest correlation after 72 h. We did not prove any significant dependency of the levels of protein S100B and patient’s age. Higher levels of protein S 100B were found in patients with additional injuries with a median of 1.250 (1.180; 3.380) μg/L compared to patients with isolated traumatic brain injury with a median of 0.438 (0.154; 0.681) μg/L. Patients with unsatisfactory clinical outcome (GCS ≤ 12) on Day 4 were found to have higher levels of protein S 100B after 24 and 72 h. The most reliable cut-off level of protein S 100B for predicting favorable clinical outcome (GCS ≥ 13) on Day 4 was possible after 72 h at the level of ≤ 0.132 μg/L with 94.1% sensitivity and 100% specificity. Conclusion: The study supports the potential prognostic use of serum S 100B protein in patients with with traumatic brain injury.

Keywords:

traumatic brain injury – protein S 100B – CT – Glasgow Coma Scale

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