Are ticagrelor and prasugrel an alternative in the antiplatelet treatment of ischemic stroke? YES

1. Kubica A, Kozinski M, Grezsk G et al. Genetic determinants of platelet response to clopidogrel. J Thromb Thrombolysis 2011; 32(4): 459–466. doi: 10.1007/ s11239-011-0611-8.

2. Kastrati A. New anti-platelet agents: the end of resistance? Thromb Res 2012; 130 (Suppl 1): S53–S55. doi: 10.1016/ j.thromres.2012.08.275.

3. Johnston CB, Amarenco P, Albers GW et al. Ticagrelor versus aspirin in acute stroke or transient ischemic attack. N Engl J Med 2016; 375(1): 35–43. doi: 10.1056/ NEJMoa1603060

4. Wiviott SD, Braunwald E, McCabe CH et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357(20): 2001–2015. doi: 10.1056/ NEJMoa0706482.

5. Ogawa A, Toyoda K, Kitagawa K et al. Comparison of prasugrel and clopidogrel in patients with non-cardioembolic ischaemic stroke: a phase 3, randomised, non-inferiority trial (PRASTRO-I). Lancet Neurol 2019; 18(3): 238–247. doi: 10.1016/ S1474-4422(18)30449-6.