Are ticagrelor and prasugrel an alternative in the antiplatelet treatment of ischemic stroke? NO

Czech version

Published in: Cesk Slov Neurol N 2019; 82(6): 614
Category: Controversions

Sources

1. ESO. European Stroke Organization: Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008. Cerebrovascular Diseases 2008. 25: 457.

2. Johnston S, Amarenco P, Albers G, & Denison H. Ticagrelor versus Aspirin in acute stroke or transient ischemic attack. N Engl J Med 2016. 375: 35-43.

3. Wiviott S, Braunwald E, McCabe C, Montalescot G, Ruzyllo W, Gottlieb S, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. The New England journal of medicine 2007. 357: 2001-2015.

4. Cattaneo M. High on-treatment platelet reactivity – definition and measurement. Thrombosis and Haemostasis 2013. 109: 792-798.

5. Collet J-P, Cuisset T, Rangé G, Cayla G, Elhadad S, Pouillot C, et al. Bedside monitoring to adjust antiplatelet therapy for coronary stenting. The New England journal of medicine 2012. 367: 2100-2109.

6. Siller-Matula JM, Francesconi M, Dechant C, Jilma B, Maurer G, Delle-Karth G, et al. Personalized antiplatelet treatment after percutaneous coronary intervention: the MADONNA study. International Journal of Cardiology 2013. 167: 2018-2023.

7. Aradi D, Tornyos A, Pintér T, Vorobcsuk A, Kónyi A, Faluközy J, et al. Optimizing P2Y12 receptor inhibition in patients with acute coronary syndrome on the basis of platelet function testing: impact of prasugrel and high-dose clopidogrel. Journal of the American College of Cardiology 2014. 63: 1061-1070.

8. Doll JA, Neely ML, Roe MT, Armstrong PW, White HD, Prabhakaran D, et al. Impact of CYP2C19 Metabolizer Status on Patients With ACS Treated With Prasugrel Versus Clopidogrel. Journal of the American College of Cardiology 2016. 67: 936-947.