A comparative study of myasthenic patients in the Czech and Slovak Republics

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Authors: M. Horáková ¹; I. Martinka ²; S. Voháňka ³; P. Špalek ²; J. Bednařík ³
Published in: Cesk Slov Neurol N 2019; 82(2): 171-175
Category: Original Paper
doi: https://doi.org/10.14735/amcsnn2019171

Overview

Aim: Existing epidemiological studies of myasthenia feature differences in incidence, prevalence, age- and gender-specific incidences, mortality rate, and even the prevalence of myasthenia subtypes. The aim of this study was to compare the overall management of patients with myasthenia, the severity of the disease, and a number of clinical and laboratory characteristics and therapy approaches amongst patients in the Czech Republic and the Slovak Republic.

Patients and methods: Data were retrospectively collected from two registries in the Czech Republic (Brno) and the Slovak Republic (Bratislava). Data were randomly matched by age of onset of myasthenia and gender. The resulting groups consisted of 152 patients each.

Results: There was almost no significant difference between the matched groups. The clinical form, positivity of antibodies to acetylcholine receptor, Myasthenia Gravis Composite Score, time to diagnosis, and percentage of thymomas and thymectomy were not significantly different. There were significant differences only in the occurrence of limb weakness at the onset of disease and in the choice of treatment modality.

Conclusions: Our data suggest that at least part of previously observed heterogeneity between populations might be based on different age and gender distribution.

捷克和斯洛伐克共和国肌无力患者的比较研究

目标：
现有的肌无力流行病学研究表明，发病率，患病率，年龄和性别特异性发病率，死亡率，甚至是肌无力亚型的患病率存在差异。本研究的目的是比较捷克共和国和斯洛伐克共和国患者的肌无力患者的总体管理，疾病的严重程度以及临床和实验室特征以及治疗方法。

患者和方法：
从捷克共和国（布尔诺）和斯洛伐克共和国（布拉迪斯拉发）的两个登记处追溯收集数据。根据肌无力和性别的发病年龄随机匹配数据。由此产生的组由152名患者组成。

结果：
匹配组之间几乎没有显着差异。临床表现，乙酰胆碱受体抗体阳性，重症肌无力综合评分，诊断时间，胸腺瘤百分率和胸腺切除术无显着差异。仅在疾病发作时肢体无力的发生和治疗方式的选择方面存在显着差异。

结论：
我们的数据表明，至少部分先前观察到的人群之间的异质性可能基于不同的年龄和性别分布。

关键词：
重症肌无力 - 人口特征 - 比较 - 登记

Keywords:

myasthenia gravis – population characteristics – comparison – registries

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