Multiple Extraneural Metastases of an Anaplastic Astrocytoma – a Case Report
Authors:
J. Hommerová 1; J. Mraček 2; P. Mukenšnabl 3; L. Holubec 4; J. Polívka 1; V. Přibáň 2
Authors‘ workplace:
LF UK a FN Plzeň
Neurologická klinika
1; LF UK a FN Plzeň
Neurochirurgické oddělení
2; LF UK a FN Plzeň
Šiklův patologicko-anatomický ústav
3; LF UK a FN Plzeň
Onkologické a radioterapeutické oddělení
4
Published in:
Cesk Slov Neurol N 2013; 76/109(6): 745-750
Category:
Case Report
Overview
Since metastasizing of intracranial tumours outside the central nervous system is an extremely rare complication, this option tends to be omitted in clinical practice. Most frequently, metastases are formed by high-grade (malignant) gliomas. They occur most commonly in the lungs and/or pleura and, alternatively, in descending order in the kidneys, adrenal glands, pancreas, spleen, heart and skin. Higher incidence of metastases is associated with neurosurgical procedures. In this report, we describe a case of a patient with anaplastic astrocytoma and pulmonary metastases with clinical signs of pulmonary involvement definitely confirmed during autopsy that also revealed further metastases in the liver, adrenal glands and lumbar vertebrae.
Key words:
extraneural metastasis – anaplastic astrocytoma – neurosurgery – chemotherapy – radiotherapy
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Sources
1. Davis L. Spongioblastoma multiforme of the brain. Ann Surg 1928; 87(1): 8– 14.
2. Šikl H. Glioma of the brain with metastasis into the lung. Acta Un Int Cancer 1950; 6: 986– 988.
3. Piccirilli M, Brunetto GM, Rocchi G, Giangaspero F,Salvati M. Extra central nervous system metastases from cerebral glioblastoma multiforme in elderly patiens. Clinico– pathological remarks on our series of seven cases and critical review of the literature. Tumori 2008; 94(1): 40– 51.
4. Schweitzer T, Vince GH, Herbold C, Roosen K, Tonn JC. Extraneural metastases of primary brain tumors. J Neurooncol 2001; 53(2): 107– 114.
5. Didelot A, Taillandier L, Grignon Y, Vespignani H,Beauchesne P. Concomitant bone marrow metastasis of a glioblastoma multiforme revealed at the diagnosis. Acta Neurochir (Wien) 2006; 148(9): 997– 1000.
6. Pasquier B, Pasquier D, N‘Golet A, Meng Hong P, Couderc P. Extraneural metastases of astrocytomas and glioblastomas: clinicopathological study of two cases and review of literature. Cancer 1980; 45(1): 112– 125.
7. Huang P, Allam A, Taghian A, Freeman J, Duffy M, Suit HD. Growth and metastatic behavior of five human glioblastomas compared with nine other histological types of human tumor xenografts in SCID mice. J Neurosurg 1995; 83(2): 308– 315.
8. Zimmermann HM. The natural history of intracranial neoplasms with special reference to gliomas. Am J Surg 1957; 93(6): 913– 924.
9. Battista AF, Bloom W, Loffman M, Feigin I. Autotransplantation of anaplastic astrocytoma into the subcutaneous tissue of man. Neurol (Minneap) 1961; 11: 977– 981.
10. Grace JT, Perese DM, Metzgar RS, Sasabe T, Holdridge B. Tumor autograft responses in patients with glioblastoma multiforme. J Neurosurg 1961; 18: 159– 167.
11. McComb JG. Recent research into the nature of cerebrospinal fluid formation and absorption. J Neurosurg 1983; 59(3): 369– 383.
12. DeAngelis LM. Brain tumors. N Engl J Med 2001; 344(2): 114– 123.
13. Weiss L. A metastasing ependymoma of the cauda equina. Cancer 1955; 8(1): 161– 171.
14. Ley A, Campillo D, Oliveras C. Extracranial metastasis of glioblastoma multiforme. J Neurosurg 1961; 18: 313– 330.
15. Stark AM, Nabavi A, Mehdorn HM, Blomer U. Glioblastoma multiforme – report of 267 cases treated at a single institution. Surg Neurol 2005; 63(2): 162– 169.
16. Hentschel SJ, Sawaya R. Optimizing outcomes with maximal surgical resection of malignant gliomas. Cancer Control 2003; 10(2): 109– 114.
17. Lakomý R, Burkoň P, Burkoňová D, Jančálek R. Nové možnosti léčby glioblastoma multiforme. Klin Onkol 2010; 23(6): 381– 387.
18. Mraček Z, Janda J. Glioblastoma multiforme s extrakraniálními metastázami. Cesk Neurol Neurochir 1975; 38(1): 19– 24.
19. Gyepes MT, D‘Angio GJ. Extracranial metastases from central nervous system tumors in children and adolescents. Radiology 1966; 87(1): 55– 63.
20. Dolman CL. Lymph node metastasis as first manifestation of glioblastoma. J Neurosurg 1974; 41(5): 607– 609.
21. Nager GT. Gliomas involving the temporal bone clinical and pathological aspects. Laryngoscope 1967; 77(4): 454– 488.
Labels
Paediatric neurology Neurosurgery NeurologyArticle was published in
Czech and Slovak Neurology and Neurosurgery
2013 Issue 6
Most read in this issue
- Tuberous Sclerosis Complex in Children Followed from Neonatal Period for Prenatally Diagnosed Cardiac Rhabdomyoma – Two Case Reports
- Frontotemporal Lobar Degeneration from the Perspective of the New Clinical‑ Pathological Correlations
- Pineal Region Expansions
- Occipital Condyle Fractures