Comparison of Results of Measurement of Visual Evoked Potentials in Patients with Multiple Sclerosis and Neuroborreliosis

Czech version

Authors: J. Szanyi; Z. Kubová; M. Kuba; J. Kremláček; J. Langrová; R. Taláb ¹; K. Honegr ²; J. Szanyi ²
Authors‘ workplace: Ústav patologické fyziologie, LF UK Hradec Králové ; Neurologická klinika a ¹; Klinika infekčních nemocí LF UK a FN Hradec Králové ²
Published in: Cesk Slov Neurol N 2007; 70/103(6): 658-664
Category: Original Paper

Tato práce vznikla s podporou IGA MZ – grant NR 8421-4 a výzkumného záměru MŠMT ČR – VZ 0021620816. Poděkování: Výsledky prezentované v této práci vznikly v Elektrofyziologické laboratoři Ústavu patologické fyziologie Lékařské fakulty UK v Hradci Králové díky technickému zabezpečení, na kterém se podíleli Ing. František Vít a Ladislava Kolková.

Overview

The aim of this study was to elucidate functional cerebral changes in patients suffering from neuroborreliosis and to compare the results with findings in clinically definite multiple sclerosis (MS). We tried to find out, whether the neuroborreliosis related impairment can be revealed by visual evoked potentials (VEPs) and if so, which of the two main parallel systems/streams of the visual pathway (parvocellular/ventral or magnocellular/dorsal) is affected predominantly. In 39 patients with MS and 100 patients with neuroborreliosis we investigated two types of VEPs – the pattern-reversal VEPs (R-VEPs) and the motion-onset VEPs (M-VEPs). In MS 25 patients exhibited pathological results in R-VEPs (significantly prolonged latency of the main P100 peak), which was accompanied by prolonged latency of the M-VEPs (N160 peak) in 14 cases. In neuroborreliosis: 46 patients exhibited pathological results in M-VEPs (significantly prolonged latency of the main N160 peak), which was accompanied by prolonged latency of the main peak of the R-VEPs (P100) in 14 cases only. Our study supports the concept of functional damage of the visual pathway in neuroborreliosis but in contrast to MS the neuroborreliosis seems to affect predominantly the magnocellular system and/or the dorsal stream.

Key words:
Visual Evoked Potentials – Multiple Sclerosis – Neuroborreliosis – Magnocellular System – Parvocellular System

Sources

1. Kuba M, Kubová Z. Visual evoked potentials specific for motion-onset. Doc Ophthalmol 1992; 80: 83-89.

2. Kubová Z, Kuba M, Spekreijse H, Blakemore C. Contrast dependence of motion-onset and pattern-reversal evoked potentials. Vision Res 1995; 35: 197-205.

3. Kubová Z, Kuba M. Zrakové vyvolané odpovědi na začátek pohybu struktury v zorném poli I – základní charakteristika. Čs Neurol Neurochir 1992; 55/88: 52-56.

4. McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al. Recommended Diagnostic Criteria for Multiple Sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis. Ann Neurol 2001; 50: 121-127.

5. Halperin JJ, Luft BJ, Anand AK, Roque CT, Alvarez O, Volkman DJ et al. Lyme neuroborreliosis: central nervous systém manifestations. Neurology 1989; 39 (6): 753-759.

6. Chabot RJ, Sigal LH. QEEG and evoked potentials in central nevous system Lyme disease. Clin Electroencephalogr 1995; 26 (3): 137-45.

7. Kubová Z, Szanyi J, Langrová J, Kremláček J, Kuba M, Honegr K. Motion-onset and pattern-reversal VEPs in diagnostics of Neuroborreliosis. Journal of Clinical Neurophysiology 2006; 23 (5): 416-420.

8. Szanyi J, Kuba M, Kremláček J, Taláb R, Žižka J. Porovnání výsledků vyšetření zrakových evokovaných potenciálů a magnetické rezonance u pacientů s roztroušenou sklerózou. Cesk Slov Neurol N 2003; 4: 258-262.

9. Bach M, Ullrich D. Motion adaptation governs the shape of motion-evoked cortical potentials. Vision Res 1994; 34 (12): 1541-1547.

10. Schellart NA, Trindade MJ, Reits D, Verbunt JP, Spekreijse H. Temporal and spatial congruence of components of motion-onset evoked responses investigated by whole-head magneto-electroencephalography. Vision Res 2004; 44 (2): 119-134.

11. Kubová Z, Kuba M, Hubáček J, Vít F. Properties of visual evoked potentials to onset of movement on a television screen. Doc Ophthalmol 1990; 75 (1): 67-72.

12. Kremláček J, Kuba M, Kubová Z, Chlubnová J. Motion-onset VEPs to translating, radial, rotating and spiral stimuli. Doc Ophthalmol 2004; 109: 169-175.

13. Langrová J, Kuba M, Kremláček J, Kubová Z, Vít F. Motion-onset VEPs reflect long maturation and early aging of visual motion-processing system.Vision Res 2006; 46: 536-544.

14. Lesser RL. Ocular Manifestation of Lyme Disease. Am J Med 1995; 98 (4): 60-62.

15. Rothermal H, Hedges TR, Steere AC. Optic neuropathy in children with Lyme disease. Pediatrics 2001; 108 (2): 477-481.

16. Ahmad A, Moriguchi T, Salem N. Decrease in neuron size in docosahexaenoic acid-deficient brain. Pediatr Neuro 2002; 26 (3): 210-218.

17. Kilic D. The effects of ageing and sulfur dioxide inhalation exposure on visual evoked potentials, antioxidant enzyme systems, and lipid-peroxidation levels of the brain and eye. Neurotoxicol Teratol 2003; 25 (5): 587-598.

18. Mitchell TV, Neville HJ. Asynchronies in the development of electrophysiological responses to motion and color. J Cogn Neurosci 2004; 16 (8): 1363-1374.

19. Kubová Z, Kuba M. Motion-onset VEPs Improve the Diagnostics of Multiple Sclerosis and Optic Neuritis. Sbor Ved Pr LF UK Hradec Králové 1995; 38 (2): 89-93.

20. Kurtz SK. Relapsing fever/Lyme disease. Multiple Sclerosis. Med Hypotheses 1986; 21: 335-343.

21. Schmutzhard E. Lyme borreliosis and Multiple Sclerosis. Biomed Pharmacother 1989; 43: 415-419.

22. Coyle PK: Borrelia burgdorferi antibodies in Multiple Sclerosis patients. Neurology 1989; 39: 760-761.

23. Karussis D, Weiner HL, Abramsky O. Multiple Sclerosis vs Lyme disease: a case presentation to a discussant and a review of the literature. Mult Scler 1999; 5: 395-402.

24. Heller J, Holzer G. Schimrigk K. ELISA for specifying oligoclonal bands of isoelectric focusing of cerebrospinal fluid in patients with Neuroborreliosis and Multiple Sclerosis. Nervenarzt 1990; 61 (4): 248-249.

25. Kaiser R. Intrathecal immune response in patients with Neuroborreliosis: specificity of antibodies for neuronal proteins. J Neurol 1995; 242: 319-325.

26. Schmutzhard E. Multiple Sclerosis and Lyme borreliosis. Wien Klin Wochenschr 2002; 114 (13-14): 539-543.

27. Hradílek P, Vlček F, Zapletalová O, Školoudík D. Vyšetření vizuálních evokovaných potenciálů a sonografické vyhodnocení orbitální hemodynamiky u akutní unilaterální optické neuritidy. Cesk Slov Neurol N 2007; 70/103 (1): 78-83.

28. Sibony P, Halperin J, Coyle PK, Patel K. Reactive Lyme serology in optic neuritis. J Neuroophthalmol 2005; 25 (2): 67-68.