5 Years of Activities of the National Reference Laboratory for Human Prion Diseases Attached to the Department of Pathology and Molecular Medicine of FTNsP: Our Experience and an Overview of Literature

Czech version

Authors: R. Matěj ¹; R. Rusina ²; F. Koukolík ¹
Authors‘ workplace: Národní referenční laboratoř lidských TSE/CJN při Oddělení patologie a molekulární medicíny FTNsP, Praha ¹; Neurologická klinika IPVZ a FTNsP, Praha ²
Published in: Cesk Slov Neurol N 2007; 70/103(6): 637-642
Category: Review Article

Poděkování: Autoři tímto děkují všem, kteří se na činnosti NRL v jejím průběhu podíleli či podílejí.
V abecedním pořadí pak zejména MUDr. Pavlu Bočanovi, CSc., RNDr. Miladě Matějčkové, ing. Janě Novákové, CSc., MUDr. Jakubu Sikorovi, ing. Aleně Srbové.

Overview

During the existence of the Czech National Reference Laboratory for Transmissive Spongiform Encephalopathies at the Department of Pathology and Molecular Medicine of Thomayer Teaching Hospital in Prague (the laboratory was established in July 2001) as many as 90 brains of patients with suspicion of Creutzfeldt-Jakob disease (CJD) have been examined. The histopathologic criteria for definite CJD were fulfilled in 50 cases. No case of the new variant of CJD has been detected in the Czech Republic. Recently, obligatory testing of brain tissue from corneal graft donors was established in the laboratory.

Key words:
prion diseases – Creutzfeldt-Jakob disease – neuropathology – diagnostics

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