Acute Choreatic Syndrome: A Case Report

Czech version

Authors: A. Kopal ¹; V. Dostál ¹; E. Krasulová ²; E. Ehler ¹
Authors‘ workplace: Neurologické oddělení, Krajská nemocnice Pardubice ¹; Neurologická klinika 1. LF UK a VFN, Praha ²
Published in: Cesk Slov Neurol N 2007; 70/103(3): 336-339
Category: Case Report

Overview

A case-report of a young woman with acute choreatic syndrome has been presented. The patient has autoimmune disorders in history (Graves-Basedow disease, idiopathic thrombocytopenic purpura) and the presence of lupus anticoagulant. Antiphospholipid syndrome was diagnosed by consequential investigations. Antiphospholipid syndrome (APS) is a thrombophilic state characterized by vascular (arterial and venous) trombosis, spontaneous pregnancy loss and the presence of antiphospholipid antibodies (anti-cardiolipin antibodies or lupus anticoagulant). The main pathogenetic mechanism is a vascular obstruction induced by hypercoagulation. APS can be primary or secondary in a variety of autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis, autoimmune thyreoiditis and others). Neurological manifestations of APS are various. There are especially ischemic stroke, cerebral venous thrombosis, migraine. Chorea or other dyskinesia, dementia, epilepsy can also occur in association with APS. In the treatment for APS aspirin and anticoagulants are recommended.

Key words:
chorea – antiphospholipid syndrome – thyreopathy – idiopathic thrombocytopenic purpura

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