Adaptation and validation of the Czech version of the Addenbrooke‘s Cognitive Examination (ACE-III-CZ) – pilot study

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Authors: H. Kisvetrová ¹; J. Tomanová ²; M. Bretšnajdrová ³; B. Jurašková ⁴; R. Herzig ⁵; H. Polanská ⁶; D. Školoudík ⁷; A. Bartoš ⁸
Authors‘ workplace: Centrum vědy a výzkumu, Fakulta zdravotnických věd UP, Olomouc ¹; Ústav pedagogiky a sociálních studií, Pedagogická fakulta UP, Olomouc ²; II. interní klinika – gastroenterologická a geriatrická LF UP a FN Olomouc ³; III. interní gerontometabolická klinika LF UK a FN Hradec Králové ⁴; Neurologická klinika LF UK a FN Hradec Králové ⁵; Fakulta tělesné výchovy UK, Praha ⁶; Centrum zdravotnického výzkumu, LF, Ostravská univerzita ⁷; Neurologická klinika 3. LF UK a FN Královské Vinohrady, Praha ⁸
Published in: Cesk Slov Neurol N 2024; 87(1): 41-47
Category: Original Paper
doi: https://doi.org/10.48095/cccsnn202441

Overview

Introduction: The Addenbrooke‘s Cognitive Examination (ACE-III) is a comprehensive tool assessing five cognitive domains (attention, memory, verbal production, language, and visuospatial ability). It is sensitive to both mild cognitive impairment and early stages of dementia and replaces an earlier version (ACE-R). Aim: Cultural adaptation and validation of the Czech version (ACE-III-CZ). Materials and methods: Healthy individuals and patients with early-stage dementia aged 60 years and older from neurological and geriatric outpatient clinics of four university hospitals were included in the study. We assessed reliability (Cronbach‘s alpha coefficient, McDonald‘s omega coefficient), concurrent validity of ACE-III-CZ and Mini-Mental State Examination (MMSE) (Pearson’s correlation coefficient), AUC values, sensitivity and specificity of the test using an ROC curve analysis. Results: The sample consisted of 250 subjects (122 with dementia [mean age 76.5 ± 7.1 years; 67.2% females] and 128 cognitively healthy [mean age 71.1 ± 5.2 years; 77.3% females]). The reliability of the ACE-III-CZ was very good (Cronbach‘s alpha = 0.906; McDonald‘s omega = 0.937). Age and level of education had significant correlation with the total score and all ACE-III-CZ domain scores (P < 0.001). A high AUC (0.996; 95% CI 0.990–1.000) confirmed a good ability of the test to differentiate between those with and without dementia. The optimal cut-off point was 89.5 with a sensitivity of 98% and a specificity of 100%. Conclusion: Results suggest a high diagnostic ability of ACE-III-CZ and its applicability in Czech clinical practice.

Keywords:

hydrocephalus – Spina bifida – neural tube defect – dementia – Cognition – Psychometrics – aging

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