Multiple system atrophy
Authors:
J. Klempíř 1,2,3; T. Bartošová 1,2
Authors‘ workplace:
Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze
1; Anatomický ústav, 1. LF UK v Praze
2; Evropská referenční síť pro vzácná neurologická onemocnění
3
Published in:
Cesk Slov Neurol N 2019; 82(4): 370-380
Category:
Review Article
doi:
https://doi.org/10.14735/amcsnn2019370
Overview
Multiple system atrophy (MSA) is relatively rare neurodegenerative disease with fatal prognosis affecting middle-aged and elderly individuals. There is combination of several motor and non-motor symptoms in MSA. Causal treatment does not exist and symptomatic treatment effect is unsatisfactory. The article briefly discusses genetics and pathophysiology of MSA with special focus on the clinical picture, practical aspects of diagnostics and current therapeutic options of MSA in the Czech Republic.
The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.
The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.
Keywords:
multiple system atrophy – atypical parkinsonian syndrome – alpha synuclein – REM sleep behavioral disorders – autonomic dysfunction – orthostatic hypotension – inspiratory stridor
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Czech and Slovak Neurology and Neurosurgery
2019 Issue 4
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