Periodic Limb Movements During Sleep are More Severe in Narcolepsy with Cataplexy than in Narcolepsy without Cataplexy

Czech version

Authors: J. Krpešová; D. Kemlink; V. Ibarburu; S. Dostálová; J. Bušková; J. Piško; P. Kovalská; I. Příhodová; K. Šonka
Authors‘ workplace: Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN v Praze
Published in: Cesk Slov Neurol N 2017; 80/113(1): 70-74
Category: Original Paper

Overview

Introduction:
Periodic limb movements in sleep (PLMS) are repetitive stereotyped movements of extremities, particularly of the legs. Some studies identified narcolepsy to be associated with higher PLMS occurrence.

Methods:
A retrospective study including 78 patients with narcolepsy with cataplexy (NC) and 29 patients with narcolepsy without cataplexy (NwoC) aged 19 to 86 years, 50 women and 57 men. All subjects underwent a clinical examination including video-polysomnography 8 hours at night time and the multiple sleep latency test (MSLT).

Results:
PLMS characterized by the periodic leg movements index (PLMI – number of periodic leg movements per 1 hour) ≥ 15 were found in 40% of the total of 107 patients – 43% of NC and 32% of NwoC. PLMS was associated with higher age and with lower sleep efficacy. The mean PLMI of NC and NwoC was different 24.3 ± 30.2 and 12.6 ± 20.8, resp. Similar values were identified when subjects not using antidepressants during the study were evaluated in these same subgroups. PLMI values (31.2 ± 33.3) were higher in patients using antidepressants than in patients never taking antidepressants (15.4 ± 23.7), irrespective of whether antidepressants were used before the study only or before and during the study. However, patients with the history of antidepressants use were older.

Conclusion:
PLMS are frequent comorbidity in NC and it is more frequent in NC than in NwoC.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Key words:
narcolepsy with cataplexy – narcolepsy without cataplexy – periodic limb movements in sleep – antidepressants – comorbidity

Chinese summary - 摘要

在睡眠中周期性肢体动作严重与猝倒发作性睡病比嗜睡症

无猝倒

摘要

简介：

在睡眠中周期性肢体运动（PLMS）特别重复动作睡眠时下肢。一些报告描述PLMS的发病率较高

发作性睡病。

方法：

78例患者从患嗜睡症与猝倒症（NK）和29的回顾性研究患者发作性睡病猝倒无（NbezK）（年龄从19年〜86岁，50名妇女和57男性）。所有患者进行临床检查，视频多导睡眠图晚上8点

在晚上的时间，多睡眠潜伏期试验。

结果：

每小时PLMS的特点是周期性运动（PLMI）≥15表明总集107例，40％的组中的NK的43％，并在基

NbezK 32％。发生PLMS与年龄和较低的时间有关效率。直径在PLMI NK（24.3±SD = 30.2）是从平均PLMI不同NbezK（12.6±20.8）和非常相似的结果在上述时所获得组进行了评价只有谁是在考试的时候治疗的患者抗抑郁药。 PLMI患者接受抗抑郁药，无论以前或在时间记录（31.2±33.3）高于谁从未接受过抗抑郁药的患者高（15.4±23.7），但患者的抗抑郁药治疗的历史是老年人。

结论：

PLMS频繁合并症NK，往往比NbezK。

关键词：

发作性睡病与猝倒 - 发作性睡病猝倒没有 - 在周期性肢体运动睡眠 - 抗抑郁药 - 合并症

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