Neutralising Antibodies and Myxovirus Resistance Protein A as a Marker of Biological Response to Interferon β

Czech version

Authors: J. Libertínová ¹; E. Meluzínová ¹; V. Maťoška ²; M. Zajac ³; E. Hynčicová ¹; A. Tomek ¹; M. Bojar ¹
Authors‘ workplace: Neurologická klinika 2. LF UK a FN v Motole, Praha ¹; Laboratoř molekulární diagnostiky Nemocnice Na Homolce, Praha ²; Ústav lékařské mikrobiologie, 2. LF UK a FN v Motole, Praha ³
Published in: Cesk Slov Neurol N 2014; 77/110(5): 638-641
Category: Short Communication

Děkuji doc. MU Dr. Petrovi Marusičovi, Ph.D. za připomínky k článku. Podpořeno grantem IGA MZ ČR NT 12385- 5.

Overview

Interferon β is the first-line treatment for relapsing-remitting multiple sclerosis. Patients treated with interferon β may develop neutralizing antibodies that can reduce or abolish its efficacy. Interferon-inducible Myxovirus resistance protein A has been proven to be a sensitive marker of biological response to interferon β. Neutralizing antibodies and the levels of Myxovirus resistance protein A mRNA are sensitive measures of biological response to interferon β; their levels should be investigated in all interferon-treated patients.

Key words:
interferon b – multiple sclerosis – neutralizing antibodies – Myxovirus resistance protein A

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

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