#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Spinal Cord Metastasis of Adenocarcinoma – Case Report


Authors: L. Hrabálek 1;  O. Kalita 1;  J. Ehrmann 2;  J. Srovnal 2;  M. Hajdúch 3
Authors‘ workplace: Neurochirurgická klinika LF UP a FN Olomouc 1;  Katedra patologie, Centrum molekulární biologie a medicíny LF UP a FN Olomouc 2;  Laboratoř experimentální medicíny, Dětská klinika LF UP a FN Olomouc 3
Published in: Cesk Slov Neurol N 2008; 71/104(5): 583-587
Category: Case Report

Poděkování: Molekulární vyšetření nádoru bylo umožněno díky grantové podpoře Ministerstva školství, mládeže a tělovýchovy (LC07017, MSM 6198959216) a Ministerstva průmyslu (MPO 1H-PK/45) České republiky.

Overview

Metastasis of adenocarcinoma to the spinal cord is a rare condition that accounts for 1–3 % of spinal tumours. The authors present the case of a 74-year-old man who suddenly developed quadriparesis and was subsequently diagnosed as a tumour of the cervical spinal cord. The spinal tumour was removed surgically and a metastasis of an adenocarcinoma was shown histologically, probably from the sigmoid colon. Early diagnosis of spinal metastases by means of magnetic resonance and microsurgical resection can improve prognosis and neurological deficit of patients to some extent. The available literature presents a total of 71 cases of surgery, which is recommended in selected cases, in particular for patients with a potentially radio-resistant metastasis. The aim of surgery is the decompression of functional nerve tissue and histological verification of the origin of the tumour. Survival time after such an operation is approximately twice that when therapy does not involve surgery.

Key words:
spinal cord metastasis – adenocarcinoma – spinal cord – operation


Sources

1. Edelson RN, Deck MD, Posner JB. Intramedullary spinal cord metastases. Clinical and radiographic findings in nine cases. Neurology 1972; 22(12): 1222–1231.

2. Jellinger K, Kothbauer P, Sunder-Plassmann E, Weiss R. Intramedullary spinal cord metastases. J Neurol 1979; 220(1): 31–41.

3. Schiff D, O’Neill BP. Intramedullary spinal cord metastases: clinical features and treatment outcome. Neurology 1996; 47(4): 906–912.

4. Schijns OE, Kurt E, Wessels P, Luijckx GJ, Beuls EA. Intramedullary spinal cord metastasis as a first manifestation of a renal cell carcinoma: report of a case and review of the literature. Clin Neurol Neurosurg 2000; 102:(4): 249–254.

5. Costigan DA, Winkelman MD. Intramedullary spinal cord metastasis. A clinicopathological study of 13 cases. J Neurosurg 1985; 62(2): 227–233.

6. Chason JL, Walker FB, Landers JW. Metastatic carcinoma in the central nervous system and dorsal root ganglia. Cancer 1963; 16: 781–787.

7. Okamoto H, Shinkai T, Matsuno Y, Saijo N.Intradural parenchymal involvement in the spinal subarachnoid space associated with primary lung cancer. Cancer 1993; 72(9): 2583–2588.

8. Grem JL, Burgess J, Trump DL. Clinical features and natural history of intramedullary spinal cord metastasis. Cancer 1985; 56(9): 2305–2314.

9. Silva YJ, McSwain B. Intramedullary spinal cord metastasis: the sole clinical manifestation of an adenocarcinoma of the colon. Can J Surg 1967; 10(3): 341–344.

10. Tanghetti B, Fumagalli GL, Giunta F, Marini G, Zorzi F. Intramedullary spinal cord metastases. J Neurosurg Sci 1983; 27(2): 117–124.

11. Connolly ES jr, Winfree CJ, McCormick PC, Cruz M, Stein BM. Intramedullary spinal cord metastasis: report of three cases and review of the literature. Surg Neurol 1996; 46(4): 329–338.

12. Ogino M, Ueda R, Nakatsukasa M, Murase I. Successful removal of solitary intramedullary spinal cord metastasis from colon cancer. Clin Neurol Neurosurg 2002; 104(2): 152–156.

13. Chen YJ, Chang GCh, Chen HT, Yang TY, Kuo BIT, Hsu HCh et al. Surgical results of metastatic spinal cord compression secondary to non‑small cell lung cancer. Spine 2007; 32(15): E413–E418.

14. Dunne JW, Harper CG, Pamphlett R. Intramedullary spinal cord metastases: a clinical and pathological study of nine cases. Q J Med 1986; 61(235): 1003–1020.

15. Guidetti B, Fortuna A. Differential diagnosis of intramedullary and extramedullary tumors. In: Vinken T, Braun G (eds). Handbook of Clinical Neurology. Amsterdam: Elsevier 1975: 51–75.

16. Hejazi N, Hassler W. Microsurgical treatment of intramedullary spinal cord tumors. Neurol Med Chir (Tokyo) 1998; 38(5): 266–271.

17. Lee SS, Kim MK, Sym SJ, Kim SW, Kim WK, Kim SB et al. Intramedullary spinal cord metastases: a single‑institution experience. J Neurooncol 2007; 84(1): 85–89.

18. Winkelman MD, Adelstein DJ, Karlins NL. Intramedullary spinal cord metastasis. Diagnostic and therapeutic considerations. Arch Neurol 1987; 44(5): 526–531.

19. Holoye P, Libnoch J, Cox J, Kun L, Byhardt R,Almagro U et al. Spinal cord metastasis in small cell carcinoma of the lung. Int J Radiat Oncol Biol Phys 1984; 10(3): 349–356.

20. Potti A, Abdel-Raheem M, Levitt R, Schell DA, Mehdi SA. Intramedullary spinal cord metastases (ISCM) and non‑small cell lung carcinoma (NSCLC): clinical patterns, diagnosis and therapeutic considerations. Lung Cancer 2001; 31(2–3): 319–323.

21. Mut M, Schiff D, Shaffrey ME. Metastasis to nervous system: spinal epidural and intramedullary metastases. J Neurooncol 2005; 75(1): 43–56.

22. Amin R. Intramedullary spinal metastasis from carcinoma of the cervix. Br J Radiol 1999; 72(853): 89–91.

23. Bizzozzero L, Ferrara M, Villa F, Fontana R, Brusamolina R, Collice M. Intramedullary spinal cord metastasis. Case report. J Neurosurg Sci 1994; 38(3): 193–195.

24. de Almeida Holanda MM, de Andrade EM, da Silva JA. Intramedullary spinal cord metastasis from thyroid carcinoma: case report. Arq Neuropsiquiatr 2006; 64(2A): 338–341.

25. Donovan DJ, Freeman JH. Solitary intramedullary spinal cord tumor presenting as the initial manifestation of metastatic renal cell carcinoma: case report. Spine 2006; 31(14): E460–463.

26. Fakih M, Schiff D, Erlich R, Logan TF. Intramedullary spinal cord metastasis (ISCM) in renal cell carcinoma: a series of six cases. Ann Oncol 2001; 12(8): 1173–1177.

27. Fischer G, Brotchi J. Intramedullary spinal cord tumors. Report. French Society of Neurosurgery. 45th annual congress. Neurochirurgie 1994; 40 (Suppl 1): 1–108.

28. Foster OJ, Crockard HA. Cervical syrinx associated with an intramedullary metastasis: case report. J Neurol Neurosurg Psychiatry 1987; 50(5): 637–639.

29. Gasser TG, Pospiech J, Stolke D, Schwechheimer K. Spinal intramedullary metastases. Report of two cases and review of the literature. Neurosurg Rev 2001; 24(2–3): 88–92.

30. Gasser T, Sandalcioglu IE, El Hamalawi B,van de Nes JA, Stolke D, Wiedemayer H. Surgical treatment of intramedullary spinal cord metastases of systemic cancer: functional outcome and prognosis. J Neurooncol 2005; 73(2): 163–168.

31. Gazzeri R, Galarza M, Faiola A, Gazzeri G.Pure intramedullary spinal cord metastasis secondary to gastric cancer. Neurosurg Rev 2006; 29(2): 173–177.

32. Grasso G, Meli F, Patti R, Giambartino F, Florena AM, Iacopino DG. Intramedullary spinal cord tumor presenting as the initial manifestation of metastatic colon cancer: case report and review of the literature. Spinal Cord 2007; 45(12): 793–796.

33. Honma Y, Kawakita K, Nagao S. Intramedullary spinal cord and brain metastases from thyroid carcinoma detected 11 years after initial diagnosis – case report. Neurol Med Chir (Tokyo) 1996; 36(8): 593–597.

34. Kalayci M, Cağavi F, Gül S, Yenidünya S,Açikgöz B. Intramedullary spinal cord metastases: diagnosis and treatment – an illustrated review. Acta Neurochir (Wien) 2004; 146(12): 1347–1354.

35. Li Y, Takayasu M, Takagi T, Yoshimoto M,Mitsui Y, Yoshida J. Intramedullary spinal cord metastasis associated with hemorrage: a case report. No Shinkei Geka 2000; 28(5): 453–457.

36. Marquart C, Weckesser M, Schueller P,Hasselblatt M, Wassmann H, Schröder J. Intramedullary spinal cord metastasis as initial presentation of a systemic cancer – report of a rare case. Zentralbl Neurochir 2007; 68(4): 214–216.

37. Mercier P, Vialle M, George B, Fardoun R,Guy G. Les metastases rachidiennes intradurales des cancers viscéraux. A propos de quatre cas. Neurochirurgie 1984; 30(3): 177–181.

38. Pelissou-Guyotat I, Guyotat J, Szapiro J,Ravon R, Moreau JJ, Vidal J. Métastases spinales intradurales de néoplasies viscérales. A propos de quatre cas. Revue de la litterature. Neurochirurgie 1989; 35(4): 236–241.

39. Raco A, Delfini R, Salvami M, Innocenzi G,Ciappetta P. Intramedullary mestastasis of unknown origin: case report. Neurosurg Rev 1992; 15(2): 135–138.

40. Watanabe M, Nomura T, Toh E, Sato M,Mochida J. Intramedullary spinal cord metastasis: a clinical and imaging study of seven patients. J Spinal Disord Tech 2006; 19(1): 43–47.

Labels
Paediatric neurology Neurosurgery Neurology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#